PRTG Manual: IPv6
PRTG supports the IPv6 protocol for most sensors. You can choose whether you want to query data from your network devices via an IPv4 or IPv6 connection. Indicate your preference in the device settings of each device. The sensors you add to the device use the protocol that you indicate.
In the Outgoing IP Settings of the PRTG Administration Tool, you can additionally choose which IPv6 address is used for outgoing monitoring requests. The same option is also available for IPv4.
Not all sensors are IPv6 compatible. You can see which sensors support IPv6 in the Add Sensor dialog. Incompatible sensors are not selectable on IPv6 devices.
The hosted probe of a PRTG hosted by Paessler instance does not support the IPv6 protocol. If you want to use sensors that support IPv6, add them to a remote probe device.