PRTG Manual: IPv6 Support
PRTG supports the IPv6 protocol for most sensors. You can choose whether you want to query data from your network devices via an IPv4 or IPv6 connection. Specify your preference in the device settings. The sensors you add to the device use the protocol that you select.
In the IPv6: Outgoing IP for Monitoring Requests setting of the PRTG Administration Tool, you can additionally select the IPv6 address that PRTG uses for outgoing monitoring requests. The same option is also available for IPv4.
Not all sensors are IPv6 compatible. Incompatible sensors are not selectable on IPv6 devices.
The hosted probe of a PRTG Hosted Monitor instance does not support the IPv6 protocol. If you want to use sensors that support IPv6, add them to a remote probe device.
For more information, see section List of Sensors with IPv6 Support.