If you dont want to see the help boxes at all, please follow these instructions:

Find the file customerscripts.js in the folder \prtg network monitor\website\javascript.

Note: All Javascript commands in this file will be added to the end of PRTG's Javascript file and changes to this file will not be overwritten when installing updates of PRTG.

Open the file in a text editor and add the following lines of code (in a default installation the file is empty):

$(function() {
    $("#openclosehandle").hide();
    $("#helpcontainer").hide();
});